PhD-position: "The Memory Function of Sleep: Reactivating lost memories using Non-Invasive Brain Stimulation (NIBS) and a Pharmacological Approach"
Deadline: 7 June 2024
Job Description
In the PI group led by Dr. Pim Heckman at Maastricht University, we study ‘The Memory Function of Sleep’. To this end, we conduct both animal and human studies. Some of this work is conducted by looking at the beneficial effects of sleep on memory, but mostly we research sleep’s role in memory by studying the negative consequences of the absence of sleep (sleep loss). Using this approach, the molecular mechanisms behind the negative effects of sleep loss on memory have largely been elucidated. This provided important insights into how sleep is relevant for memory formation during sleep. What remained unknown, however, was the question of to what extent these memories are lost. Recent work of our lab, using a combined optogenetic and pharmacological approach, revealed that memories compromised by sleep loss are not completely lost and can even be artificially retrieved in rodents. The current project aims to translate these findings to the human setting. A challenge that arises is the need for a human-applicable alternative for optogenetic memory reactivation. We successfully used subliminal reactivation paradigms to this end. However, this only results in temporary restoration of the memory. We are searching for means to make the restored memories permanently accessible again. The current PhD project aims to investigate the potential of a pharmacological approach as well as non-invasive brain stimulation (NIBS) in combination with subliminal memory reactivation. The NIBS studies are conducted in direct collaboration with experts in the field (i.e., Prof. Alexander Sack and Dr. Vincent van de Ven at the Department of Cognitive Neuroscience at Maastricht University).
Requirements
- (Research) Master’s degree in neuroscience or equivalent
- Demonstrated ability to work independently as well as in a team
- Experience in human behavioral testing/studies
- (At least some) experience in computational modelling/programming is desired
- A personality characterized by communicative, collaborative, and organizational skills
- Good oral and written English communication
- Strong ethical stance in conducting and reporting on empirical scientific research
- During the 4 years in Maastricht, the candidate will spend 5% of the time on teaching (i.e., tutoring, assist in neuroanatomy practical, etc.) with the option to start obtaining the University
- Teaching Qualification UTQ (in Dutch BKO)). Some interest in or affinity with teaching is highly recommended.
Are you interested in this exciting position but still have questions? Feel free to contact Dr. Pim Heckman at